Breast Cancer and
Almost all the cells
in your body are being created, live a certain length of time, and then die to
make place for the new cells coming along. White blood cells last only two days.
Red blood cells last 120 days. Your skin cells are being made new all the time.
They are the ones that flake off when you take a bath and make a ring in the
tub. This programmed cell death is called apoptosis.
What has been
discovered is that the cells that become cancer cells are not only those that
are multiplying rapidly. White blood cells multiply rapidly and they don't
become cancer cells. Rather, it's the ones that don't die on time. They don't go
Apoptosis; Estrogen Turns If Off
Research has looked
into what it is that makes a cell do this. It is not instructed by some other
cell. It is built into the DNA of the genes of that cell. It's designed that
way. It turns out that there's a gene that will block apoptosis and try to get
the cell to live longer. That gene is called BCL2. BCL2 leads to the cell
becoming a cancer cell.
Breast Cancer Cells
Need Apoptosis In Order To Die
The cancer cell
doesn't think of itself as a bad cell. It thinks of itself as a cell that
outsmarted you, and it is going to live on. You might die, but it is going to
try to live on.
The gene that normally
functions to cause that cell to commit apoptosis is called P53. In the 1/28/98
issue of the Journal of the American Medical Association (JAMA) is an article
entitled "To Die or Not to Die." The article discusses the cell and
what controls and determines if it dies on time as it should. They refer to gene
P53 as the gene that tells the cell to die on time, and BCL2 is the gene that
blocks this. So if BCL2 is the dominant one you will develop cancer. If P53 is
the dominant one you won't.
Inside your breast you
have skin cells that line the milk ducts. You have miles of milk ducts in your
breasts. These cells are like skin cells. They are being made; then they are
supposed to die, and the specialized blood cells (macrophages) eat them up,
because new cells are coming along all the time. Imagine if they didn't die on
time, and you just retained all these cells that are being constantly made.
Pretty soon your breasts would be dragging on the ground. The only way you keep
normal size breasts is to have last month's cells die to make room for this
month new cells. What keeps you young and healthy are those new cells coming
along all the time.
Can You Cure Cancer
if You Can Control Apoptosis?
The JAMA article
admits that the war on cancer has been a failure. The war on cancer has been
trying to find medicine that stops rapidly growing cells from multiplying so
rapidly, but in the process they are stopping your own white blood cells, your
hair follicles and everything else. So if they give you a medicine strong enough
to kill the cancer cells, they are in the process -- killing you.
They admit that
chemotherapy is a failure, except for some leukemias and lymphomas in very young
children. Young children who have a real strong immune system will survive the
chemotherapy and come back, expecially if they still have stem cells. But for
those of us who are adults the chemotherapy strong enough to kill the cancer
would have to be strong enough to kill us first. So now, the new treatment goal
is how to control apoptosis to bring on cell death of the cancer cells.
the Gene that Causes Cancer Cells To Die
Estrogen Boosts the
Gene that Cause Cancer Cells Not to Die
In 1997, Dr. Ben
Formby and Dr.T.S. Wiley at the University of California in Santa Barbara proved
how to do that very thing. Dr. Formby is a molecular biologist from Copenhagen,
Denmark, who has learned how to build cell cultures, and how to tell what
specific genes like BCL2 and P53 produce. So he took the cell cultures of
breast, endometrium, ovary and prostate, and he grew them in cultures.
On some he added a
little estrogen (estradiol). Guess what happened. The estradiol turned on BCL2,
and the cells grew rapidly and didn't die. Then he added some progesterone to
it. Guess what happened. They stopped growing so rapidly; they died on time, and
the cancer all disappeared. He did that for all these types of cancer.
So what do these
studies tell us? The BCL2 gene stimulates the risk of cancer. Gene P53 decreases
the risk of cancer. Estradiol boosts BCL2. Progesterone boosts P53. Therefore
having the correct amount of progesterone in your system is what keeps cancer
under control. Unopposed estradiol causes cancer.
Decreases Cell Proliferation: Estrogen Increases It
Another JAMA article
was the first double blind, placebo controlled, randomized study using
transdermal progesterone and transdermal estrogen (estradiol) on real women (40
of them) who were having breast biopsies. They had one at the beginning of the
study and another 13 days later, and were able to check on several interesting
The first thing of note was that even though the estrogen and
the progesterone did not show up in the serum, it showed up in the breast tissue
at over 100% increased levels above the placebo cream. The most interesting
finding was what happened to cell proliferation during this 13 day test. The
following chart shows two ways of measuring cell proliferation. The PCNA
(proliferating cell nuclear antigen) is the most accurate, but both methods were
Method of Measuring Cell Proliferation
Estrogen & Progesterone
Mitosis per 1000 Cells
The numbers on the above chart were
excerpted from the Fertility and Sterility Journal, Vol. 63, No. 4, April, 1995.
The exact reference is: Chang KJ, Lee TTY , Linares-Cruz G, Fournier S, de
Lignieres B. Influences of percutaneous administration of estradiol on human
breast epithelial cell cycle in vivo. Fertility and Sterility 1995; 63;
Based on PCNA numbers (these tend to be the most accurate
measurement) the numbers in the chart showing increase or decrease of cell
proliferation showed up in only 13 days. Translated into percentages the
following 3 sentences summarize it.
1. Topical Progesterone reduced
cell proliferation by 410%
2. Topical Estrogen increased cell
proliferation by 223%
3. Topical Estrogen/Progesterone
combination reduced cell proliferation by 16%