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The Most Powerful Immune Booster Known


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A Bitter Sweet Reality

The article below was written in March 2000.  I used this product, MGN3, for three weeks to completely eradicate my cancer in June 2000 per my retest two weeks after treatment ended.  As you will read later, there is now a replacement product available called ImmPower.

I offer this information in a effort to open your eyes to one tiny but integral piece of the "real" world that was pulled out from under you.  I've left the original article largely in-tack so you can glean the importance of this remarkable rice bran/mushroom supplement and its potent immune boosting power - that was quietly removed from the market overnight by the FDA. 

Everything in this article can be said for the replacement supplement ImmPower, which some say is even stronger than the original MGN3.  So if you just received that dreaded cancer diagnosis, don't despair.  Between the time you're diagnosed and your next appointment, you can be cured if you act quickly. 


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Louis Pasteur is credited with giving the world his theory that germs were the cause of disease and for 100 years now, conventional medicine has been based on Pasteur's work. Researchers and doctors have operated under the belief that disease is caused by the invasion of germs, and to eliminate disease these invading microbes have to be destroyed. 

In our continuing quest to eliminate these microbes, our medicines have become increasingly more potent. While this has led to a great deal of success in healing many infections, it has also exposed a number of germ theory's shortcomings. As a result, many researchers are now rethinking the theory's validity.

Two Schools of Germ Theory

Over the years, two schools of thought concerning health and healing have emerged. Conventional medicine and its disciples have accepted germ theory in its entirety--that the road to disease is paved with microbes, and to remain healthy these microbes must be eliminated. They believe this can best be accomplished through the use of drugs, particularly antibiotics.

The pharmaceutical industry loves this idea. Since there are literally millions of different microbes all around us, it stands to reason that thousands of different medicines will be needed to destroy them. This translates into billions of dollars in profits, both from the sale of the drugs and the hundreds of testing procedures required to identify each of the pathogenic microbes involved and the effectiveness of the drugs used.

The second school of thought opposes both the idea of using drugs to destroy microbes as well as the basic premise that microbes are the sole cause of all disease. We live in an environment teeming with millions if not billions of microbes. These organisms inhabit and thrive in our air, water, soil, and even in our bodies. Thanks to the delicate yet very complex actions of our immune system, we are able not only to survive but actually thrive in this microbe-infested environment. An active, healthy immune system is the one thing that keeps us alive.

The Second School champions the importance of the immune system in health and healing. Under normal circumstances, our immune systems are able to destroy harmful microbes while leaving benign varieties alone. Health problems, therefore, occur not simply because we've been exposed to one microbe or another, but because our immune systems are not functioning as well as they should be. This helps explain why not everyone exposed to the cold virus comes down with a cold, or why some people are able to avoid and recover from deadly diseases like cancer while others cannot.

When illness does take hold, followers of the second school of thought believe that emphasis should be placed on boosting the immune system through nutrition and other natural techniques. They recognize the importance of enhancing the body's own innate healing powers through a proper diet and lifestyle.

To put it mildly, the pharmaceutical companies haven't been too supportive of this latter idea. There's not as much profit involved in promoting the use of whole, natural foods, herbs and vitamins as there is in selling drugs. As such, for years the pharmaceutical companies and many individuals within the medical profession have been trying to persuade the public that "alternatives" to drugs are a waste of time and money at best and outright quackery at worst. Recent trends and events, however, have begun to prove them wrong.

We Now Know that Drugs are Not the Total Solution

Over the past few years, we have been witnessing the backlash of germ therapy in the form of deadly, antibiotic-resistant bacteria. As a result of being "attacked" by stronger and stronger antibiotics, several strains of bacteria have mutated and developed a resistance to all forms of medication currently available.

It should come as no surprise, then, that more and more people are dying of cancer each year. The toxic drug and radiation treatments heralded as the solution just aren't working as expected. Similarly, AIDS researchers have determined that bombarding the body with anti-viral medications isn't the answer. With AIDS, there are a number of different viruses at work (HIV, HHV-6B, etc.), and developing a specific medication for each and every one could take decades or longer. To complicate matters even further, viral mutations occur quite rapidly and can quickly make a promising medication useless. And very often the side effects of these drug treatments prove to be far more deadly than the virus itself.

Be it AIDS, cancer, or other deadly and seemingly incurable diseases, current research is confirming that therapies which hold the greatest promise are the more natural, less toxic ones that work in conjunction with the immune system.

A few short years ago, any comment about a substance's ability to "boost the immune system" would have brought howls of laughter and condemnation from the medical community. Nowadays, however, this same concept seems to be all the rage among both traditional and conventional medical practitioners. Slowly but surely, modern medicine is beginning to understand the vital importance of enhancing the body's own disease-fighting capabilities.

Quite Possibly The Most Powerful Immune Booster Known to Man

The work doctor Dr. Mamdooh Ghoneum awakened many in conventional medicine to the enormous benefits of using natural immune-enhancing compounds.  Dr. Ghoneum worked with the Department of Immunology at Drew University in Los Angeles. For six years he worked on an amazing product called MGN3. The only published information about it was buried in technical medical journals. Why? The answer may surprise you.

Dr. Ghoneum was educated in Egypt and Japan, and continues to spend much of his time in those countries. His work with MGN3 began in Japan, where he is quite well-known. (He just finished his sixth book in Japanese, all of which deal with cancer.) As with most new therapies, his initial research was performed in vitro and later using animal models. Although the results were extremely positive, he refused to publicize the data until he was sure that similar results could be duplicated in humans. In a world where new fads based on just the slightest hint of benefit pop up almost daily, it's refreshing and unusual to meet someone willing to forgo publicity in an effort to perform actual human studies.

Thanks to Dr. Ghoneum, we had excellent research data showing that MGN-3 was likely the most powerful human immune system booster on the market, prescription or otherwise. Even more amazing is the fact that it had no known side effects. The implications this substance could have had on your personal health are astounding.

MGN3 Combined a Potent Antiviral Extract with the Three Top Cancer Treatments in Japan

MGN3 was produced by integrating, through hydrolysis, an extract from the outer shell of rice bran with the extracts from three different mushrooms: Shiitake (yielding Lentinan), Kawaratake (yielding Krestin), and Suehirotake (yielding Sizofiran).

On their own, extracts from rice bran exhibit fairly strong antiviral effects. And extracts from each of these three mushrooms have been found to have anti-cancer properties. In fact, in Japan, these three mushroom extracts have become the three leading prescription treatments for cancer. In the years to come, mushrooms may become a primary source of natural medicines all over the world. Of the million or so known varieties, only a small handful have been categorized and analyzed. One of the challenges of using mushrooms medicinally is that they seem to work differently with different people.  This may be due to the various blood types.  Fortunately, the benefits of MGN-3 were very consistent and predictable.

Natural Killer Cells

The human immune system is comprised of more than 130 subsets of white blood cells. In order to understand just how powerful an immune stimulator MGN3 is and how you can use it to help treat a wide variety of serious health problems, you need some background information on one of the most common forms of white blood cells.

Natural Killer (NK) cells make up roughly 15% of all human white blood cells. They provide the first line of defense for dealing with any form of invasion to the body--sort of like elite military soldiers who are called upon to seek out and destroy dangerous invaders.

Each cell contains several small granules which act as "ammunition." Once an NK cell has recognized a cancer cell, for example, it attaches itself to the cell's outer membrane and injects these granules directly into the interior of the cell. The granules then "explode," destroying the cancer cell within five minutes. The undamaged NK cell then moves on to other cancer cells and repeats the process. When the immune system is particularly strong, active NK cells will often take on two cancer cells or other infected cells at the same time.

NK Activity, Not Volume, Determines the Strength of the Immune System

Unlike other white blood cells, inadequate numbers of NK cells are very rarely a problem. Instead, it is the activity of the cells that generally determines whether one is sick or healthy. As long as the NK cells are active (just as soldiers remain on "active" duty, ready for battle), everything remains under control. If cells lose their ability to either recognize or destroy the invader, however, the situation can deteriorate rapidly. In AIDS and cancer patients, NK cell activity is probably the primary criteria for estimating the chances of survival. It's pretty much accepted that when NK cells cease to function, the end is near.

In addition, research has now confirmed that individuals with low NK cell activity are significantly more susceptible to autoimmune diseases, chronic fatigue immune dysfunction (CFIDS, or chronic fatigue syndrome), viral infections, and the development of cancerous tumors. (We haven't been able to verify that the same holds true in humans, but animal research has also shown that females commonly have lower NK cell activity than males.)

Doctors can test NK cell activity with a test called the NK cell function test. Basically, a blood sample is taken from the patient and placed in a vial containing live tumor cells. After four hours, a count is taken to determine what percentage of the cancer cells have been destroyed by the NK cells. The higher the percentage, the more active the cells.

Technically, the test is referred to as the 4 hour 51Chromium-release assay. I'm certainly not advocating that everyone go out and have it done, but if you have been dealing with one of the conditions listed above or have had any sort of longstanding infection, it may be a good idea. If your local lab doesn't perform the test, your doctor can order it from Specialty Labs in Santa Monica, California at 800-421-7110.

How did MGN3 Increase NK Cell Activity

MGN3's ability to boost NK activity and overall immunity appeared to stem from four things.

1) It increased the number of explosive granules in NK cells. The more granules a NK cell carries, the more cancer and virus-infected cells it can destroy.

2) It increased  interferon levels. Interferon is another potent compound produced by the body that both inhibits the replication of viruses and other parasites and increases NK cell activity.

3) It increased the formation of Tumor Necrosis Factors (TNFs). TNFs are a group of proteins that help destroy cancer cells.

4) In addition to increasing NK activity as much as 300% (or even higher), oral ingestion of MGN3 increased  the activity of other key immune cells, like T-cells (200%) and B-cells (250%).

Dr. Ghoneum's years of research proved just how powerful MGN3 was at boosting NK cell activity and combating a wide range of diseases, although the majority of his work was with cancer patients.


Unlike most forms of cancer treatment, MGN3 was totally non-toxic. After years of use and continued toxicity tests, there had never been any indication of toxicity or side effects whatsoever. Undoubtedly, this is because MGN3's primary function was to enhance the activity of the immune system rather than to attack cancer cells directly. This also helps explain why it seemed to work well for all types of cancer.


Research Shows that NK Activity Shoots Up Within Two Weeks and Continues To Rise

Dr. Ghoneum ran numerous NK cell activity tests on patients with all types of cancers. In 80% to 90% of his cancer patients, their NK cells could only kill about 20 to 30% of the cancer cells during the first hour of the test. After just two weeks of taking MGN3, however, the kill percentage jumped to 60 to 70% in 99% of the patients.

Dr. Ghoneum presented the results from one of his studies involving five patients with breast cancer at the November 5, 1995 meeting of the American Association for Cancer Research. Each patient was treated with the same dosage of 3 grams per day of MGN3. NK cell activity increased within two weeks and continued as the study progressed. At the end of the six to eight-month study, two of the patients were already in complete remission.

Another study of Dr. Ghoneum's involved 27 cancer patients ranging in age from 42 to 57. The types of cancers involved included breast, cervical, prostate, leukemia, and multiple myeloma. All patients had low NK cell activity at the beginning of the study. After only two weeks, the NK cell activity had increased as follows: breast carcinoma 154-332%, cervical carcinoma 100-275%, prostatic cancer 174-385%, leukemia 100-240%, and multiple myeloma 100-537%. Remember, this was after just two weeks of MGN3, and NK activity continued to rise throughout the six-month study. (Study reported at the 87th annual meeting of the American Association for Cancer Research, April 20, 1996.)

MGN3 Helped Cancers That Are Unaffected by Angiogenesis Inhibitors

MGN3 filled a gap left by many of the other natural therapies, in particular the class of therapies known as angiogenesis inhibitors.

Angiogenesis inhibitors work by cutting off the blood supply to tumors. Whether they be natural products like shark cartilage or pharmaceutical ones like endostatin and angiostatin, these angiogenesis inhibitors aren't very effective at treating blood cancers such as leukemia, lymphatic cancer or lung cancer. In each case, the explanation for this ineffectiveness is fairly simple. Because leukemia is a cancer of the blood cells themselves, cutting off the blood supply to these cells is simply impossible. With lymphatic cancer, it's the lymphatic fluids, not blood vessels, that supply lymph cells with all of their necessary nutrients, so again, cutting off the blood supply is futile. And because the lungs have such a rich and complex supply of blood vessels, there's really no effective way to restrict blood flow to that area.

None of these factors posed a problem for MGN3. By increasing the activity of NK cells, which naturally circulate in the blood and lymph systems, MGN3 was used effectively for all of these cancers. The NK cells don't have to penetrate deep into massive hard tumors to get to active cancer cells-they simply identify and eliminate the cancer cells they "encounter" in the blood or lymph.

MGN3 Even Worked with Multiple Myeloma, One of the Deadliest Cancers

In another study involving 11 patients, the percentages of patients experiencing complete remission with MGN3 were as follows:

1) Prostate cancer, two of the three patients, or 66%. (Note: All of the prostate patients experienced a decline in PSA levels. One reached a normal level after one month on MGN3, another's was normal after two months, and the third patient's dropped from 87.2 to 7 after four months.)

2) Ovarian cancer, two of the three patients, or 66%.

3) Breast cancer, one of the three patients, or 33%. (The other two had partial remission.)

4) Multiple myeloma, one of the two patients, or 50%. (Int J Immunotherapy 95:XI (1):23-28)

While all of these results are impressive to say the least, the case of the multiple myeloma patient is particularly remarkable. Multiple myeloma is a very rare and fatal cancer. It makes up only about one percent of all cancers, and among oncology circles it is considered practically incurable. Without treatment, a patient almost always lives less than a year. With chemotherapy, some have been known to live two years.

The multiple myeloma patient who experienced complete remission was a 58-year-old male diagnosed in October, 1990. He first had several months of chemotherapy following his diagnosis. Although everything seemed to have stabilized, his laboratory work still showed specific blood markers for multiple myeloma eight months after the chemotherapy. He then began taking the MGN3, and in less than six months follow-up lab work revealed no indication of cancer. Dr. Ghoneum said, this was the first patient who has been known to survive multiple myeloma.

MGN3 Lessened Toxicity and Improves Effectiveness of Conventional Therapies

MGN3 also lessened the toxic side effects of conventional cancer treatment. Chemotherapy and radiation destroy several white blood cells in the process of trying to destroy cancer. Taking MGN3 concurrently with these treatments helped prevent this effect. Many chemotherapy patients taking MGN3 also reported less difficulty in swallowing and less burning of the tongue.

In addition, MGN3 was used effectively with interleukin-2, the only prescription item that seems to come close to matching its immune-boosting power. (Although there are other natural products that have immune-boosting capabilities, such as CoQ10, none have been proven in human studies to be more powerful than MGN3.)

Interleukin is a protein that is normally produced in the body. Much like MGN3, it also activates certain white blood cells. To potentiate the effects of this protein, scientists isolated and synthesized it into a chemical called interleukin-2 (IL-2). This extract is then injected into patients to help stimulate their immune systems.

Although IL-2 is gaining popularity as a cancer treatment, it can trigger extremely severe and life-threatening side effects. At the therapeutic doses used for cancer, interleukin-2 causes leaks in the small capillaries. These leaks result in a loss of blood pressure, weight gain, fluid retention, difficulty breathing, and heart problems. Continued use can cause kidney failure, respiratory arrest and death. In this way, it represents yet another cancer treatment that often kills the patient before it kills the cancer. Expense is also a factor. A single inter-leukin-2 treatment can cost as much as $100,000.

Dr. Ghoneum's research has revealed that when MGN3 is used along with interleukin-2, the dosages of interleukin-2 can be reduced to extremely low levels--levels which are low enough to avoid the severe side effects. When used together, these two products had a synergistic effect that dramatically exceeds that of either used individually. Once this knowledge became public, one would have thought more oncologists would utilize it.

Pre-Cancerous Cells (Cervical Dysplasia)

Another of Dr. Ghoneum's studies involved seven female patients whose pap smears indicated the presence of abnormal cells. This is not an uncommon finding, and while these cells are not cancerous, they are often referred to as precancerous because of their propensity to develop into cervical cancer.

The severity of cervical dysplasia, as the problem is termed medically, is classified in four stages depending on the degree of abnormality in the cells. Stage I is generally a "wait-and-watch" situation, stages II and III are considered surgical cases, and stage IV is considered cancer.

In this study, Dr. Ghoneum found that using MGN3 in stage II and stage III patients completely resolved the problem. After six months of MGN3 use, with no other form of treatment, all follow-up exams and tests were normal. Some of the women have continued on maintenance doses of MGN3 at 1 gram per day. Others have discontinued its use. Two to three years after the study, none of the women has experienced recurrence, including women who discontinued the product after only six months.

Additional Therapeutic and Preventive Applications for MGN3

Dr. Ghoneum has performed an amazing amount of valuable research in just the last six or seven years but in light of his limited time and research funding, he's had to concentrate his efforts on life-saving areas like cancer and AIDS. Based on what he has already uncovered, however, it is clear that his product holds great promise for many other conditions.

Earlier in this article, I cited chronic fatigue syndrome as one of those conditions. Additionally, MGN3 could prove to be a lifesaver when it comes to any chronic or severe bacterial, viral or fungal infection.

Dr. Ghoneum has defined what he calls "high risk" categories, and he believes that individuals in these categories could also benefit from MGN3 mainly as a form of disease prevention. Included in these would be:

  • Heavy smokers (those smoking two packs or more per day)
  • Heavy drinkers
  • Individuals who constantly work with paint (artists, house painters, etc.)
  • Individuals born with immune deficiencies
  • Families with a strong history of cancer
  • Chemical and refinery workers


The dosages Dr. Ghoneum has used in his studies are scientifically based on repeated NK cell activity tests. As such, they are very consistent and easy to follow. They fall into two categories:

1) For cancer, HIV, or other life-threatening condition, 3 grams per day for two weeks, then 1 gram per day until the problem is resolved. Some of the people Dr. Ghoneum has worked with continue to take the maintenance dosage even after the problem has been resolved, while others stop taking it and resume if the problem returns.

2) As a form of prevention, 1 gram per day. Just to reiterate, MGN3 is completely non-toxic and there's no danger whatsoever in taking it long-term. Many people stay on it for life.

In all of his studies, Dr. Ghoneum found that taking 3 grams a day resulted in a dramatic increase in NK cell activity within one to two weeks. At the lower dosage of only 1 gram per day, the same activity wasn't reached until about four weeks. This explains the initial heavy doses of 3 grams per day. Even after the dosage is dropped back to 1 gram per day, NK cell activity will continue to increase.

It is best to take the MGN3 capsules with meals in divided doses. For example, when taking 3 grams a day (which works out to 12 capsules), 4 capsules can be taken with each meal. When you drop down to 1 gram a day (four capsules), you can take two capsules at breakfast and two at dinner.

Product Availability

MGN3 was a patented product manufactured by the Daiwa Pharmaceutical Company in Tokyo, Japan. Currently in the US, our enlightened FDA has removed this life-saving supplement from the market citing that it required drug approval.  A year or so later a new product became available called ImmPower that is purported to be even more potent.  A quick internet search will yield it's price and availability.


Other Considerations

Based on his research and experience, Dr. Ghoneum's believes that, depending on the type and location of the cancer, surgery or a few cycles of chemotherapy or radiation therapy may be justified. He compared treating cancer to trying to wipe out a city of terrorists. By bombing the city, you would likely take care of the majority of the terrorists, accepting the fact that some non-terrorists would also be killed. Chemotherapy, radiation or surgical removal of the tumor are the cancer-equivalents of the bombing, and the beneficial white blood cells in the area are the non-terrorist victims.

Even after the bombing, however, there would always be some terrorists who could survive. The same holds true for cancer cells that were resistant to or able to survive the therapy. But rather than bomb the city again, which would only result in total destruction, special forces should be sent in to locate and eliminate the remaining terrorists one by one. This is where MGN3 comes in.

Dr. Ghoneum feels that after surgery or a minimal number of chemo or radiation treatments, MGN3 should be used exclusively to activate the immune system and let it do its work. He also clarified that he would begin using MGN3 at the very first sign of any type of cancer, not just after conventional treatments had been completed.

Dr. Ghoneum had some strong opinions regarding the use of any drugs or nutritional products during the treatment period. For all of the people he's worked with, he recommended that only necessary prescription drugs be continued (such as those for diabetes, high blood pressure, thyroid, etc.). In addition, because his research did not examine the combined effects of nutritional supplements and MGN3, he recommended that patients concentrate on getting vitamins and minerals solely from natural foods and juices (organic carrots and other freshly made fruit and vegetable juices).

Through his work with the immune system, Dr. Ghoneum has also found that poor sleeping habits and unresolved stress have a major negative impact on the activity of NK cells. He felt very strongly that both of these problems must be addressed if one expects to strengthen the immune system.  MGN3 provided a safe and effective way of doing just that. It was for a short while the most powerful immune stimulant man had uncovered and it may have been our best hope in conquering the world's deadliest diseases.


My Observations

Since my first bout with cancer, I have used ImmPower many times.  It hasn't failed me yet.  If you find yourself in this dreaded situation, don't despair.  Cancer is only a label.  You don't have to accept it. 


All illness, simply put, is an imbalance of the basic structure/function of the body.  What better way to correct the problem than to go to the core.  Strengthen your immune system so it can function normally.  Do this before any treatment... before anyone has the chance to frighten you into believing the worst.


In short, when you're scared, it's not usually the best time to make a life-altering decision.  Knowledge breeds confidence.  Do your homework now while you're not under pressure.  Listen only to your own inner voice.  Don't allow well-meaning loved ones, acquaintances or doctors to muddy up your mind.  It can literally mean the difference between life and death.

Never forget that your life is yours and it's a do-it-yourself job.  Don't give your power away to someone else. (They don't know any more than you do.)  So clear your mind, relax, envision a positive outcome... and treat the whole issue as a problem you have the ability to solve.  Stay focused on what you know and where you want to go.  Then... move forward.

If you wish further guidance on designing a plan of action, you may contact me through my Wellness Connection.

Good luck and good health,



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